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Supplementation with secondary bile acids can alleviate inflammation in acute and chronic colitis models in mice (Sinha et al., 2020), and remodeling the gut microbiota to improve bile acid metabolism can reduce colitis (Zhou et al., 2023)

Given the constitutive activity of the ghrelin receptor, inverse agonists would be the target of pharmacological agents for maximal efficacy 24

There may be several explanations for this effect

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That means rebuilding a balanced eating pattern, increasing nutritional variety, and developing habits that can realistically continue beyond the short-term program