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When researchers and staff internalize this philosophy, clinical trials not only become more ethical but also more efficient, ultimately contributing to improved data quality and accelerated advancements in medical research

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J Appl Physiol 112(1):197203 Salehpour M, Khodagholi F, Zeinaddini Meymand A, Nourshahi M, Ashabi G (2018) Exercise training with concomitant nitric oxide synthase inhibition improved anxiogenic behavior, spatial cognition, and BDNF/P70S6 kinase activation in 20-month-old rats

Constipation, while less common than diarrhea, may also occur and can be particularly problematic in patients with pre-existing constipation issues