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In some cases, somebody sections have more melanin than others, making them appear darker in colour

However, the mechanisms of combined therapies have not been fully elucidated, which limited the clinical application of these drugs

Gotlib J, George TI, Carter MC, Austen KF, Bochner B, Dwyer DF, Lyons JJ, Hamilton MJ, Butterfield J, Bonadonna P, Weiler C, Galli SJ, Schwartz LB, Elberink HO, Maitland A, Theoharides T, Ustun C, Horny HP, Orfao A, Deininger M, Radia D, Jawhar M, Kluin-Nelemans H, Metcalfe DD, Arock M, Sperr WR, Valent P, Castells M, Akin C

E.lvarez-ArellanoL.Corts-MendozaJ.et al (2019)

Duration : Fast-absorbing IM shot, typically completed in under 5 minutes Add-on option : Can be paired with IV therapy for enhanced effect