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Therefore parenterally administered aminoglycosides do not cross lipid membranes well and do not achieve therapeutic concentrations in milk, accessory sex gland fluids, abscesses, or cerebrospinal fluid

Therefore, most cancer cells rely on nutrient transporters that can import extracellular cystine (the oxidized dimer form of cysteine) (, which is a sodium-independent, chloride-dependent, anionic L-cystine/L-glutamate antiporter on the cell surface ( SLC7A11 gene in humans is located on chromosome 4 and the SLC7A11 protein has orthologs in all vertebrates ( and, therefore, serves as the primary transporter for cystine and glutamate ( Extracellular cystine is imported into the cell through SLC7A11 and is converted to cysteine through a NADPH-consuming reduction reaction in the highly reducing atmosphere of the cytosol

[DOI] [PubMed] [Google Scholar] Usuki F, Yamashita A, Fujimura M