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From a therapeutic perspective, the central role of GPX4 is not equivalent to the only critical node

Cobalamin (Cbl) has the ability to bind to various functional groups

This, in turn, can impact the integrity of the neural retina resulting in thinning of the outer nuclear layer (Karlstetter et al., 2015

The polar active site has also contributed to ligand binding by forming ion-dipole interactions with Gln 33

We also observed that the binding of the E protein with TMED10 does not inhibit but rather enhances the association between TMED10 and IL1 (Supplementary Fig