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The rearrangement is accompanied by a cis-trans isomerization of this proline, which likely increases the energy required for the transition between the 2 states, and may play a role in the stabilization of the active conformation at the water/lipid interface

doi: 10.1038/nri.2016.70 61 AdamikJMunsonPVHartmannFJCombesAJPierrePKrummelMFet al

But there is a creme available called Man1 Man Oil that repairs these endings with a protein called acetyl L carnitine

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Although AOX therapy offers theoretical benefits, clinical outcomes remain inconsistent