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These results indicate that the substrate specificity of the latter differs fundamentally from that of its non-mammalian homologs

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PMID: 12201498

What the evidence does not yet support: Definitive dosing and duration recommendations

Consistent with the results acquired from PC cell lines, PDCs with low expression of VRK2 were more sensitive to APR-017 treatment than PDCs with high expression of VRK2 (Fig