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Kruse T, Hansen JL, Dahl K, Schaffer L, Sensfuss U, Poulsen C, et al

The accumulation of ROS overwhelms endogenous antioxidant defenses, creating a vicious cycle of oxidative damage

These are preclinical findings, not human clinical proofs

Minocycline acts by inhibiting MMP-9 and the p38 mitogen-activated protein kinase signaling pathways, thereby reducing the production of glutamate, IL-1, and NO by microglia [305]