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7 Semaglutide-treated KO mice similarly failed to suppress RER or elevate circulating long-chain acylcarnitines and were resistant to GLP1R agonist-induced body weight and adipose mass loss (Fig

3D) was elevated in the PXN HIGH and CAF HIGH groups compared to PXN LOW and control (group age interaction and pairwise comparisons

Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control

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However, translating these mechanistic insights into clinical benefit is hindered by three interconnected challenges, each of which offers critical directions for future investigation