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To investigate astrocyte uncoupling and the development of chronic mesial temporal lobe epilepsy (MTLE), several studies utilized transgenic mice lacking CX30 and CX43 in astrocytes, the deficiency of which resulted in hyperexcitability (Wallraff et al., 2006), but not spontaneous seizures or abnormal EEG response (Chever et al., 2016)

doi: 10.3389/fbioe.2022.918659 Received 12 April 2022 Accepted 18 May 2022 Published 01 July 2022 Volume 10 - 2022 Edited by Simon J Moore, University of Kent, United Kingdom Reviewed by Yoav S

Mar 27 2020;21(7)doi:10.3390/ijms21072317 Dhar AK, Barton DA

10.1080/22311866.2019.1698317 82 HaridasM.SasidharV.NathP.AbhithajJ.SabuA.RammanoharP