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Pharmacological Inhibition of Cystine-Glutamate Exchange Induces Endoplasmic Reticulum Stress and Ferroptosis

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Sahu, S

Surprisingly, inhibition of GSH synthesis by BSO was unable to change the distribution of cellular GSH, showing a cellular glutathione pattern different from the one shown in the DEM-treated cells

As shown in the score plots in Fig 4A and in Fig S5A, the greatest impact on the metabolic profile was found in Tbx1 +/ mice treated with vB12, revealed by the distance between this class (filled triangles) compared with the PBS-treated classes: WT (empty dots) and Tbx1 +/ (empty triangles) along the first component t (1) axis (x-axis)