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doi:10.1097/mcg.0b013e3181e883dd 66Sternthal MB, Murphy SJ, George J, et al

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

MYCN -amplified HR-NB tumors, which have high metabolic needs, are dependent on iron and cysteine (key for glutathione production), making them potentially sensitive to ferroptotic cell death 7,8,9