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In contrast, although maximum lifespan of the ctl-2(ua90)II strain after HS was increased from 13 to 15 d (13% increase), the median lifespan was unchanged and measured as 10 d for both HS and OGT ctl-2(ua90)II worms (Fig 1B)

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The oral intake of ERGO also rescued age-related impairments in learning and memory ability, which might be associated with suppression of the age-related decline in hippocampal neurogenesis and TDP43 protein aggregation and promotion of microglial shift to the M2 phenotype by ERGO ingestion