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Among the several mechanisms proposed in attributing the ability of PPAR ligand in inhibiting leiomyoma cell growth, Houston suggested that the inhibition was mediated by negative cross-talk between ER and PPAR signaling pathway where the activation of PPAR inhibits ER-mediated gene expression (Houston et al., 2003)

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[83] Other gastrointestinal symptoms that may occur include abdominal discomfort, dyspepsia, and changes in bowel habits