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Further research revealed that the overexpression of AURKA mitigates diabetic limb ischemia by enhancing ferroptosis and inhibiting oxidative stress and lipid peroxidation both in vitro and in vivo [188]

The administration of Loigolactobacillus coryniformis K8 has shown promising effects, such as increasing the IgA response in correlation with the activation of TGF-, a key signaling molecule involved in immune regulation and tolerance

The combination of an anti-PD-1 antibody with lumacaftor (in micromolar doses), an FDA-approved small molecule inhibitor of DUSP18, has been shown to synergistically enhance antitumor immunity