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Shin S, Jo H, Agura T, Jeong S, Ahn H, Kim Y, Kang JS

The answer, for any rational researcher, is zero

NAD+ levels decline 15-65% with age across tissues , triggering DNA damage, mitochondrial dysfunction, and cellular senescence that accelerate aging processes

The classic presentation of thiamine deficiency is known as beriberi, which is characterized by nerve involvement and can lead to symptoms such as ataxia, oculomotor abnormalities, and aphonia