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To ensure the safety of study participants, FIH trials are preceded by preclinical tests in in vitro and in vivo experimental models

This condition is known as bursitis

Maccario M, Aimaretti G, Grottoli S, Gauna C, Tassone F, Corneli G, et al

PubMed 22962027 TB-4 Phase 1 human safety first-in-human randomized, double-blind, single- and multiple-dose Phase 1 of recombinant human thymosin 4 in healthy volunteers, no serious adverse events: PubMed 34346165

Together these compounds engage complementary signaling pathways allowing researchers to examine tissue repair mechanisms and actin cytoskeletal dynamics in controlled laboratory models