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This is the primary pathway for detoxifying acetaminophen (paracetamol), heavy metals, and numerous environmental toxins [2][6]

J Biol Chem 293(8):28772887 Csibi A, Lee G, Yoon SO et al (2014) The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

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This is unsurprising as the RPE has a high level of metabolic activity, and therefore oxygen demand, making it a significant source of ROS [17]

Success relies on following the start low, go slow dosing plan