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Decreased SIRT1 activity leads to reduced production of peroxisome proliferator activated receptor coactivator-1a (PGC-1a) and autophagy (Lim et al., 2012), loss of resistance to ROS, suppression of FOXO, inhibition of AMPK, and activation of p53, resulting in cellular senescence and renal injuries ( 4.2.6 Abnormality of immune system For children with CKD, they show accelerated immune maturation and impaired immune function, and are forced into a state of premature immune senescence ( 5 Targeting renal senescence in therapy of CKD At present, the treatments of CKD are mainly focused on the etiology, symptoms and complications

The negative slope value of sleep-deprived mice treated with GHK (SD + GHK) was similar to the negative slope value of non-sleep-deprived mice treated with saline (Control)

doi: 10.1021/CB1001558 196 World Health Organization