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When the air temperature was rapidly decreased from 89F to 54F (32C to 12C), women in their luteal phase (and those on oral contraceptives) started shivering at higher core body temperatures indicating an increased sensitivity to the cold 1

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That said, Wegovy is FDA-approved and widely prescribed for weight loss with excellent clinical responses, while retatrutide is still an investigational drug only available through clinical trials and its long-term safety and tolerability are still being studied