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During deep sleep: Growth hormone secretion peaks, driving tissue repair and muscle recovery The brains glymphatic system clears metabolic waste products, including proteins associated with neurodegeneration Cortisol levels reach their daily minimum, allowing the adrenal system to reset Immune function regenerates Cellular repair mechanisms run at maximum efficiency Most adults spend less time in deep sleep than optimal, and this deficit increases with age, stress, alcohol consumption, and certain medications

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Serum minerals There was a trend ( p = 0.055) towards higher serum Ca concentration in T1_HS and T2_HS compared to CON and CON_HS

Blood pressure should be monitored while taking it and discontinuation should be tapered

Ancestry-specific intronic variants on the APOE4 haplotype influence enhancer activity and interaction with APOE promoter