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The trial that used N -acetyl-l-cysteine as a primary treatment noted no significant differences in adverse events between the treatment and placebo groups, although both groups demonstrated a high rate of gastrointestinal symptoms and one participant in the active treatment phase required termination due to increased agitation ( Three DBPC studies, one small (110), one medium (111), and one medium-to-large (109) sized, were conducted using sapropterin as a treatment for ASD

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