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However, two fragments ZT275 and ZT320, which are located at the substrate-binding site of MmaA4, induce rearrangement of a segment (residues 147154 loop) to generate a new conformation, and cause the inability of the cofactor to be compatible with the MmaA4, which indicates that the allosteric inhibitors of MmaA4 can be designed [58]

Although several in vitro preclinical studies have shown that pharmacologically achievable concentrations of ascorbate have cytotoxic effects on cancer cells [4,5,6], AA has shown limited efficacy in some clinical trials [7, 8] but good efficacy in others [9]

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J Forensic Leg Med 14, 2007