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Full text: #MALO #VCTE #FIB4 CUHK Medicine To view or add a comment, sign in (NASDAQ: #DNLI) The New England Journal of Medicine has published Phase 1/2 data showing Denalis Hunter syndrome drug tividenofusp alfa (DNL310) can cut cerebrospinalfluid heparan sulfate by about 90% to normal or nearnormal levels and improve or stabilize cognition, behavior, hearing, liver size, and other clinical measures in most treated children, bolstering its case for FDA priority review and potential accelerated approval

Sajan M, Hansen B, Ivey R et al (2016) Brain insulin signaling is increased in insulin-resistant states and decreases in FOXOs and pgc-1 and increases in A1-40/42 and phospho-tau May Abet Alzheimer development

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