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This study established the core evidence that drives current research interest and it is important to note that this is primarily a preclinical (mouse) evidence base

known cases of chronic disease under treatment such as tuberculosis, diabetes, hypertension, hypo or hyperthyroidism, pernicious anaemia, Crohns disease and current use of anticonvulsant drugs

It is vital for red blood cell production, and maintaining a healthy nervous system, and plays a key role in DNA synthesis

However, during an initial loading phase, a more frequent schedule may be necessary

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