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Overall, the entry of drugs into the CNS depends on the pharmacokinetics (PK) parameters of drugs, such as molecular size, electric charge, lipophilicity, plasma protein binding, affinity to diffusion/active transport systems at the BBB and BCSFB, and pharmacodynamic (PD) factors such as CSF flow in the brain

Disadvantages of antimicrobial peptides as therapeutic drugs in general i , Antimicrobial peptides generally are susceptible to proteolytic degradation