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Proponents argue that the current Biden-era restrictions on compounding of the substances due to safety concerns and a lack of data have fueled a gray market of overseas suppliers, raising safety concerns as Americans inject themselves with unvetted substances

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Another RAMIRIS trial compared the safety and efficacy of FOLFIRI plus ramucirumab with paclitaxel plus ramucirumab for the same patients, and the results showed that FOLFIRI plus ramucirumab has a relative advantage in terms of the objective response rate (ORR), mPFS, and mOS (69)