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While vaccinations have been used preventatively in COVID-19, and other therapies exist to treat active infection, including antivirals, and while vaccinations and treatment can reduce a patients chances of both contracting the disease as well as developing complications such as acute respiratory distress syndrome, patients can still contract the disease and experience poor outcomes

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Ogino T, Takeda K

Second, metabolic stress, often accompanied by ATP depletion, limits the cells capacity to reconvert PGA to glutamate via 5-oxoprolinase, resulting in excess PGA being released into the plasma [42]