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Although these mechanisms have been predominantly characterized in non-tumor systems, they provide important conceptual frameworks for understanding the directionality and execution of mitochondrial transfer under metabolic stress

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Although Italian researchers first developed PDRN in the 1990s for wound healing, Korean clinics advanced its aesthetic use in the early 2000s through skin booster injections associated with the coveted glass-skin effect

However, the precise mechanisms by which these drugs exert their protective effects, particularly in relation to mitochondrial function, remain a subject of ongoing research and debate