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Mitochondria affect ferroptosis at the level of the cytosolic iron pool regulation by fine-tuning the iron influx from the cytosol into mitochondria, at the level of electron transport chain by adjusting mitROS generation and oxidative phosphorylation via AMPK activation in the energy-deficient state, and at the level of tricarboxylic acid (TCA) cycle affecting the content of NADPH and GSH [162, 166]

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These findings suggest that KDS12025 has the potential to pharmacologically activate the pseudoperoxidase activity of Hb, enabling effective H 2 O 2 decomposition events at minimal Hb levels

Cell 157 , 15771590 (2014)