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mtDNA from hepatocytes released into circulation promote inflammation through binding to endosomal TLR9 of liver resident Kupffer cells ( 6 in Figure 1) ( Non-alcoholic fatty liver disease is a vivid example of how systemic immune responses are regulated by metabolism, and that harmful local fibrosis of the liver can develop if these systemic metabolic disturbances remain unresolved

In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

doi: 10.1289/ehp.7505 41 Ben-YosefD

Woodward, and H

[DOI] [PubMed] [Google Scholar] 527.A Wadhwani S., Gorain M., Banerjee P., Shedbalkar U.U., Singh R., Kundu G.C., A Chopade B