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Particularly in the context of PD, the concern for a limited capacity for long-distance axonal growth in the adult brain, has prompted the investigation of delivering growth-promoting cues in the striatum or the nigrostriatal bundle to guide axonal projections from homotopic transplants placed in the SNpc toward the striatum and reconstruct the lost midbrain DA pathways

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Heffernan 2001a Mouse studies using chronic osmotic pump delivery showed AOD-9604 increased fat oxidation and plasma glycerol (a lipolysis marker) to a degree comparable with full-length hGH, without inducing hyperglycaemia or reducing insulin secretion

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