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Conclusion: Evidence indicated that supplementation with riboflavin, omega-3 fatty acids, alpha lipoic acid, magnesium, probiotics, coenzyme Q10, ginger, and caffeine would have favorable effects on migraine patients

UVR disrupts microbial equilibrium through direct DNA damage and indirect release of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), such as oxidized lipids and porphyrins, promoting pathogenic overgrowth (e.g., Staphylococcus aureus )

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Sinn HP, Schneeweiss A, Keller M, Schlombs K, Laible M, Seitz J, et al

Pan-cancer studies further validate IPAs causal role: its supplementation improves ICI response rates across malignancies (110, 159), while ATB-induced microbiota depletion reduces IPA levels and blunts T cell-mediated tumor controlan effect reversed by exogenous IPA, which directly upregulates granzyme B/perforin in T cells (111)