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These studies implicated enolase as the key mediator in the glycolytic inhibition

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101 Whereas, the classical explanation is that, while hydroxychloroquine impaired phago/lysosomal function, it also appears to work in a lysosome-independent manner by impacting on intracellular TLRs, particularly TLR9, by inhibiting the production of TNF, and by interfering with the processing of the conversion of the membrane-bound pro-TNF into soluble mature protein

The cold shower alcohol myth is another variant of the alertness-versus-BAC confusion

The authors also would like to thank the ESRF synchrotron (Grenoble, France) for beamtime and the beamline staff for assistance during diffraction data collection