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Selective estrogen receptor modulators (SERMs) are a class of compounds that inhibit the estrogen signaling pathway and cell cycle progression, which consequently inhibits cell growth [6]

The corresponding DNA damage includes single strand breaks, base damage, abasic sites, double strand breaks, non-double strand break clustered lesions, and complex double strand break, some of which are induced by DNA related protein (such as histone) damage ( Figure 1 )

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