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USA 118 , e2016066118 (2021)

About twice as many children receiving guanfacine had statistically significant improvement on the Clinical Global Impressions Improvement scale

Another characteristic feature is resorptive loss of acral bone (acro-osteolysis), in particular at the terminal phalanges, at the distal end of the clavicles, and in the skull (pepper-pot aspect) (Figure 17)

To address heterogeneity and missing values inherent in multi-omic datasets, emerging deep-learning models such as IMOVNN have been deployed to impute incomplete data, facilitating disease prediction and the identification of critical biomarkers [565]