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Further investigation of the interplay between opioid receptors likely will reveal novel mechanisms that mediate antinociception and contribute to opioid tolerance

Methods: Blood samples were collected from patients with advanced hepatocellular carcinoma before initiating the atezolizumab and bevacizumab treatment Patients were categorized into responders (those exhibiting stable disease, partial, or complete response) and non-responders (those showing disease progression)