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High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid

[0311] Accordingly in various embodiments, isolated anti-ALPP/ALPPL2 are provided as well as chimeric moieties comprising the anti-ALPP/ALPPL2 antibodies joined to an effector

People with one A allele for this mutation have a 35% lower and people with AA genotype 68% lower enzyme activity [42]

Arginine metabolism in myeloid cells in health and disease

The undifferentiated human monomyelocyte PLB-985 and gp91 phox KO-PLB-985 (PLB-985-KO) cells [22, 23] were cultured in a complete medium RPMI 1640, supplemented with 1% P/S, and 10 % heat-inactivated FBS