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Injection frequency also varies by peptide: some protocols are daily, while others such as BPC-157 use a 5-days-on, 2-days-off structure

The most consistently recommended practical step, across the community discussion of this topic, is starting at a reduced frequency rather than daily use from the outset: two to three applications a week for the first couple of weeks, building up to daily use gradually rather than all at once

The result is a sustained decline in sex steroid hormones, a state sometimes described medically as chemical castration in men or hypogonadism in both sexes

One study with volunteers found even people without sensitive skin experienced a significant reduction in stratum corneum integrity and induced mild erythema

The consequences are particularly interesting if one looks at the cells that compose the gut wall: when they burn food for energy (rather than fermenting it for building blocks or energy storage), the level of oxygen near the gut wall drops (von Martels et al., 2017), and the microbiota as a whole becomes more anaerobic and healthier (Litvak et al., 2017)