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Copper toxicity in the pathogenesis of age-related diseases such as neurodegenerative diseases, diabetes, and atherosclerosis has been examined and reviewed extensively elsewhere (Uriu-Adams and Keen, 2005)

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184 : 23992404 Eguchi Y, Shimizu S and Tsujimoto Y (1997) Intracellular ATP levels determine the cell death fate by apoptosis or necrosis

Stem Cell Res Ther 9(1):216 Huang Y, Zhu M, Liu Z, Hu R, Li F, Song Y, Geng Y, Ma W, Song K, Zhang M (2022) Bone marrow mesenchymal stem cells in premature ovarian failure: mechanisms and prospects

Furthermore, the epidermis is a formative barrier that functions in preventing diffusion of molecules to the underlying dermis [2, 3]