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GO term enrichment was then assessed using the enrichGO function from the ClusterProfiler 30 R package, with the parameter universe set to include all genes detected in the bulk RNA-seq data, minGSSize set to 10, maxGSSize set to 500 and pAdjustMethod set to BH

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The other authors declare no conflicts of interest

Furthermore, recent research has demonstrated that PKD3 regulates insulin sensitivity, lipid accumulation, and fibrogenesis in the liver (Mayer et al, 2019