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1 Introduction Colorectal cancer (CRC) remains a major global health burden, ranking as the third most frequently diagnosed cancer and the second leading cause of cancer-related mortality worldwide ( de novo anti-tumor immune response

Furthermore, in vivo studies using the Balb/c nude mouse xenograft model with MHCC97-H cells have shown that treatment with varying doses of corilagin (10, 20, or 30 mg/kg) results in a significant reduction in tumor mass and volume, demonstrating a dose-dependent inhibition of tumor growth

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