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doi: 10.1530/EC-23-0462 16 GuoR.SpyropoulosF.MichelT

Furthermore, PFOA increased liver-to-body weight ratio, in all genotypes and both sexes, indicating that liver enlargement occurs at least partially through non-PPAR dependent mechanisms

Moreover, the contribution of ferroptosis in non-lethal pathological cell states [e.g., inflammatory PT cell aggregation (201, 202)] show efficacy, but their active ingredients, direct molecular targets, and standardized formulations are poorly defined, hindering clinical development