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Tobin J, Rogers A, Winterburn I, et al

HR=1.72, 95% CI 1.09-2.72)

Aberrant recruitment of histone deacetylase complexes by oncoproteins such as AML1ETO and PMLRARA enforces chromatin compaction at promoters of tumor-suppressor and differentiation-related genes, thereby preserving oncogenic transcriptional programs, preventing normal myeloid maturation, and fostering chemotherapeutic resistance in AML