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Allen, M., Bailey, C., Cahatol, I., Dodge, L., Yim, J., Kassissa, C., Venketaraman, V

In addition, hemodynamic alterations, such as increased cardiac pre- and afterload, contribute to mechano-energetic uncoupling in HF, especially with preserved ejection fraction (HFpEF), which results in mitochondrial oxidative stress as an important upstream mediator of cardiac remodeling and dysfunction [2]

This article summarizes the protein characteristics, enzyme properties, and PTMs of GPX4

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