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Mln4924 exerts a neuroprotective effect against oxidative stress via Sirt1 in spinal cord ischemia-reperfusion injury

Dixon, S.J., Lemberg, K.M., Lamprecht, M.R., et al

Unlike at sites 1 and 2, where methionine residues provide axial coordination for CoPP, binding at site 3 appears to be mediated by axial chloride ligands 49 , which are stabilized through interactions with R313, Y431, and R435