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The approval is supported by three Phase III trials, including INTEGUMENT-1 and INTEGUMENT-2

[0319] In some embodiments, the compositions comprise an anti-acne ingredient (e.g., salicylic acid)

On the other hand, it is well-found that in vivo, macrophage activation occurs along with pro-inflammatory and anti-inflammatory conditions, with a degree of flexibility in both directions (Yamada and Kielian 2019)