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321 Similarly, orosomucoid-like (ORMDL) proteins, which mediate feedback inhibition of de novo sphingolipid synthesis, are implicated in inflammation and the progression of autoimmune diseases

Treatment with sucrose at concentrations above 400 mmol/L significantly shortened the average lifespan of nematodes, whereas for fructose and glucose, the turning points were 500 mmol/L and 520 mmol/L, respectively