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Monitoring components may include: Subjective Assessment: Regular evaluation of energy levels, overall wellbeing, and specific symptoms or concerns that prompted glutathione therapy

Indeed elevated levels of ROS (during radio- or chemotherapy) induced the translocation of Nrf-2 to the nucleus, where it bound to the antioxidant response element (ARE) or the electrophile-response element in the promoter region of Nrf-2, targeting antioxidant and anti-apoptotic genes, including heme-oxygenase 1 (HO-1) (Pan et al., 2013

Reactive oxygen species (ROS) generated during normal metabolism and in pathological conditions induce lipid peroxidation with consequent formation of reactive carbonyl species (RCS) such as 4-hydroxytrans-2-nonenal (HNE) that can deplete reductants including glutathione resulting in damage to cellular macromolecules such as lipids, proteins, and nucleic acids eventually culminating in tissue injury

This is why it is commonly supplemented intravenously

BILAG: British Isles Lupus Assessment Group