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As a medical device, it is FDA approved but hasnt been tested like pharmaceuticals would be to the highest level of medical evidence and scrutiny

Plant Cell Rep 37:387392 Hoekenga OA, Maron LG, Pieros MA, Canado GMA, Kobayashi JOY, Ryan PR, Dong B, Delhaize E, Sasaki T, Matsumoto H, Yamamoto Y, Koyama H, Kochian LV (2006) AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminium tolerance in Arabidopsis

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Researchers are currently exploring how neurofeedback can help with chronic pain by targeting pain-related brainwaves

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